Gene Expression | Biology News by Biologged

What is wrong with some ancestry testing

This is an example of the type of question I receive all the time: Here is some genetic analysis of Somalis from yours truly. Source: Discover Magazine – Gene Expression Tags: genomics, genetics Read more...

Posted
February 28th, 2013

Tagged
gene expression
genetic analysis
somalis

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Visualizing European genetic variation: looking at dimensions which aren’t so boring

Yesterday I re-ran Plink with a narrower European-biased data set, and generated some MDS plots. I only had a few Asian and African populations, mostly so that I could replicate the standard dimensions 1 and 2, producing the classic “v-shape” which you’ve seen before. But what’s more interesting are lower coordinates. They may not capture as much of the variation in the distance matrix, but illustrate important dynamics. I Read more...

Posted
February 14th, 2013

Tagged
african populations
gene expression
genetic variation

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Synthetic circuit allows dialing gene expression up or down in human cells

Source: ScienceDaily – Gene Therapy Tags: gene expression, molecular biology Read more...

Posted
February 12th, 2013

Tagged
gene expression
gene therapy
human cells

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Visualizing genetic variation

I’ve been thinking about how best to visualize PCA/MDS type of results, which allow for the two dimensional representation of genetic variation. Below are a few of my efforts with a data set I have. You can see the individuals in gray, but also ellipses which cover ~95% of the distribution of a given population. Please click the images for a larger version. They represent coordinate 1 on the y axis and 2 on the z axis derive from a multidim Read more...

Posted
February 12th, 2013

Tagged
dimensional representation
gene expression
genetic variation

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Autism speaks through gene expression

Source: ScienceDaily – Gene Therapy Tags: biology, genetics Read more...

Posted
February 3rd, 2013

Tagged
autism
gene expression
gene therapy

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$99 for 1 million markers

Looks like 23andMe has a new price point. If so, that’s 100 markers per cent! (here’s the press release) 1) Privacy: Yes, this a privacy risk. 23andMe is fundamentally an IT company, and IT companies mess up. But I am confident that within 10-15 years genetic information is going to be pretty easy to get anyhow. Your data will be in too many places for any expectation of privacy. 2) Cost/worth it: That is dependent on your income. I Read more...

Posted
December 11th, 2012

Tagged
gene expression
privacy risk
sequence data

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More diversity in the Personal Genome Project

Seeking Diversity (Especially Families): Because the PGP is self-recruiting, we don’t have a very balanced set of participants. “Self-recruitment” means that all participants have enrolled in our project through word of mouth, finding our website and enrolling online. To put it bluntly, that means we mostly end up with young white men…. …Research within one or two racial/ethnic categories isn’t necessarily a virtue, biracial a Read more...

Posted
December 3rd, 2012

Tagged
ethnic categories
gene expression
multiracial heritage

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Can your genes be patented?

Court to Decide if Human Genes Can Be Patented. So it seems a group of middle aged to very aged lawyers will decide the decades long Myriad Genetics saga. My position on this issue is simple: if you are going to award patents, they must be awarded to acts of engineering, not discoveries of science. See Genomics Law Report for more well informed commentary. Source: Discover Magazine – Gene Expression Tags: genetics, biotechnology Read more...

Posted
December 1st, 2012

Tagged
gene expression
human genes
myriad genetics

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