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Scientists discover structure of protein essential for quality control, nerve function

Nature Related images(click to enlarge) Image courtesy of the Wilson, Carragher and Potter labs, The Scripps Research Institute. Using an innovative approach, scientists at The Scripps Research Institute (TSRI) have determined the structure of Ltn1, a recently discovered "quality-control" protein that is found in the cells of all plants, fungi and animals. Ltn1 appears to be essential for keeping cells’ protein-making machinery Read more...

Posted
January 15th, 2013

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Chemists devise inexpensive, benchtop method for marking and selecting cells

Nature Chemists at The Scripps Research Institute (TSRI) have found an easier way to perform one of the most fundamental tasks in molecular biology. Their new method allows scientists to add a marker to certain cells, so that these cells may be easily located and/or selected out from a larger cell population. The technique, which is described in a recent issue of the chemistry journal Angewandte Chemie International Edition, makes use of the tigh Read more...

Posted
January 9th, 2013

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New study defines the long-sought structure of a protein necessary for cell-cell interaction

Nature Related images(click to enlarge) Photo courtesy of the Izard lab, The Scripps Research Institute, Florida campus. Scientists know that cells in all higher organisms need to bind to each other for the development, architecture, maintenance and function of tissues. Mysteries have remained, however, about exactly how cells manage this feat. Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now solved part of Read more...

Posted
January 7th, 2013

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Chinese medicine yields secrets to scientists at The Scripps Research Institute

Nature Related images(click to enlarge) Image courtesy of the Schimmel lab. The mysterious inner workings of Chang Shan — a Chinese herbal medicine used for thousands of years to treat fevers associated with malaria — have been uncovered thanks to a high-resolution structure solved at The Scripps Research Institute (TSRI). Described in the journal Nature this week, the structure shows in atomic detail how a two-headed compound deri Read more...

Posted
December 25th, 2012

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Chinese medicine yields secrets to scientists at The Scripps Research Institute

Nature Related images(click to enlarge) Image courtesy of the Schimmel lab. The mysterious inner workings of Chang Shan — a Chinese herbal medicine used for thousands of years to treat fevers associated with malaria — have been uncovered thanks to a high-resolution structure solved at The Scripps Research Institute (TSRI). Described in the journal Nature this week, the structure shows in atomic detail how a two-headed compound deri Read more...

Posted
December 25th, 2012

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Scripps Florida scientists create new approach to destroy disease-associated RNAs in cells

Nature Related images(click to enlarge) Photo courtesy of The Scripps Research Institute. Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new approach to alter the function of RNA in living cells by designing molecules that recognize and disable RNA targets. As a proof of principle, in the new study the team designed a molecule that disabled the RNA causing myotonic dystrophy. The study, published o Read more...

Posted
December 23rd, 2012

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Energy-sensing switch discovery could have broad implications for Biology & Medicine

Nature Related images(click to enlarge) Photo courtesy of The Scripps Research Institute Biochemists at The Scripps Research Institute (TSRI) have discovered a genetic sequence that can alter its host gene’s activity in response to cellular energy levels. The scientists have found this particular energy-sensing switch in bacterial genes, which could make it a target for a powerful new class of antibiotics. If similar energy-sensing switc Read more...

Posted
October 22nd, 2012

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The smell of Mom: Scientists find elusive trigger of first suckling in mice

Nature Related images(click to enlarge) Courtesy of The Scripps Research Institute A team led by biologists at The Scripps Research Institute has solved the long-standing scientific mystery of how mice first know to nurse or suckle. This basic mammalian instinct, which could be a key to understanding instinctive behavior more generally, was thought to be triggered by a specific odor (pheromone) that all mouse mothers emit. But, as described on Read more...

Posted
October 5th, 2012

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Neuroscientists find brain stem cells that may be responsible for higher functions, bigger brains

Nature Related images(click to enlarge) Photo courtesy of the Scripps Research Institute Scientists from The Scripps Research Institute have identified a new stem cell population that may be responsible for giving birth to the neurons responsible for higher thinking. The finding also paves the way for scientists to produce these neurons in culture — a first step in developing better treatments for cognitive disorders, such as schizophren Read more...

Posted
August 10th, 2012

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New drug-screening method yields long-sought anti-HIV compounds

Nature Related images(click to enlarge) photo courtesy of The Scripps Research Institute. Scientists at The Scripps Research Institute have used a powerful new chemical-screening method to find compounds that inhibit the activity of human immunodeficiency virus (HIV), the virus that causes AIDS. Unlike existing anti-HIV drugs, the compounds bind to a protein called "nucelocapsid," which is unlikely to mutate into drug-resistant forms Read more...

Posted
June 18th, 2012

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