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Fishing for answers to autism puzzle

CAMBRIDGE, Mass. (June 19, 2012)—Fish cannot display symptoms of autism, schizophrenia, or other human brain disorders. However, a team of Whitehead Institute and MIT scientists has shown that zebrafish can be a useful tool for studying the genes that contribute to such disorders. Led by Whitehead Member Hazel Sive, the researchers set out to explore a group of about two dozen genes known to be either missing or duplicated in about 1 percen Read more...

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August 5th, 2012

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Fishing for answers to autism puzzle

Nature Fish cannot display symptoms of autism, schizophrenia, or other human brain disorders. However, a team of Whitehead Institute and MIT scientists has shown that zebrafish can be a useful tool for studying the genes that contribute to such disorders. Led by Whitehead Member Hazel Sive, the researchers set out to explore a group of about two dozen genes known to be either missing or duplicated in about 1 percent of autistic patients. Most of Read more...

Posted
June 20th, 2012

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Once again, Whitehead Institute is the best place for postdocs

CAMBRIDGE, Mass. (March 29, 2012) – For the third time in the past four years, Whitehead Institute has been dubbed the best place in the United States for postdoctoral researchers to work. The honor was announced today by The Scientist magazine, which conducts an annual survey of postdocs at research institutions internationally. This year, more than 1,500 postdocs provided their input. In the survey’s 10 years of existence, White Read more...

Posted
April 29th, 2012

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Theory of the “rotting” Y chromosome dealt a fatal blow

CAMBRIDGE, Mass. (February 22, 2012) – If you were to discover that a fundamental component of human biology has survived virtually intact for the past 25 million years, you’d be quite confident in saying that it is here to stay. Such is the case for a team of Whitehead Institute scientists, whose latest research on the evolution of the human Y chromosome confirms that the Y—despite arguments to Read more...

Posted
February 22nd, 2012

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Theory of the “rotting” Y chromosome dealt a fatal blow

CAMBRIDGE, Mass. (February 22, 2012) – If you were to discover that a fundamental component of human biology has survived virtually intact for the past 25 million years, you’d be quite confident in saying that it is here to stay. Such is the case for a team of Whitehead Institute scientists, whose latest research on the evolution of the human Y chromosome confirms that the Y—despite arguments to Read more...

Posted
February 22nd, 2012

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Theory of the “rotting” Y chromosome dealt a fatal blow

CAMBRIDGE, Mass. (February 22, 2012) – If you were to discover that a fundamental component of human biology has survived virtually intact for the past 25 million years, you’d be quite confident in saying that it is here to stay. Such is the case for a team of Whitehead Institute scientists, whose latest research on the evolution of the human Y chromosome confirms that the Y—despite arguments to Read more...

Posted
February 22nd, 2012

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Chaos in the cell’s command center

CAMBRIDGE, Mass. (February 1, 2012) – A defective operating system is never a good thing. Like computers, our cells depend on operating systems to drive normal functions. Gene expression programs comprise the software code our cells rely on, with each cell type controlled by its own program. Corrupted programs can trigger disease. Cellular operating systems can be corrupted by viruses, mutations, or malfunctions that occur as cells change f Read more...

Posted
February 17th, 2012

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Prions play powerful role in the survival and evolution of wild yeast strains

Nature Prions, the much-maligned proteins most commonly known for causing "mad cow" disease, are commonly used in yeast to produce beneficial traits in the wild. Moreover, such traits can be passed on to subsequent generations and eventually become "hard-wired" into the genome, contributing to evolutionary change. Prions were first found to produce heritable new traits more than a decade ago in laboratory studies of simple bak Read more...

Posted
February 16th, 2012

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Prions play powerful role in the survival and evolution of wild yeast strains

CAMBRIDGE, Mass. (February 15, 2012) – Prions, the much-maligned proteins most commonly known for causing “mad cow” disease, are commonly used in yeast to produce beneficial traits in the wild. Moreover, such traits can be passed on to subsequent generations and eventually become “hard-wired” into the genome, contributing to evolutionary change. Prions were first found to produce heritable new traits more than a dec Read more...

Posted
February 15th, 2012

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Not all cellular reprogramming is created equal

CAMBRIDGE, Mass. (December 1, 2011) – Tweaking the levels of factors used during the reprogramming of adult cells into induced pluriopotent stem (iPS) cells greatly affects the quality of the resulting iPS cells, according to Whitehead Institute researchers. “This conclusion is something that I think is very surprising or unexpected—that the levels of these reprogramming factors determine the quality of the iPS cells,” say Read more...

Posted
December 1st, 2011

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